2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. 5-HT Receptor

5-HT Receptor

Serotonin Receptor; 5-hydroxytryptamine Receptor

5-HT Receptor

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5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100820R
    Sarizotan (Standard)
    		Agonist
    Sarizotan (Standard) is the analytical standard of Sarizotan. This product is intended for research and analytical applications. Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.
    Sarizotan (Standard)
  • HY-123442
    L 775,606
    		Agonist
    L 775,606 is a potent and selective 5-HT1D receptor agonist. L 775,606 can be used to study migraine headache.
    L 775,606
  • HY-A0019R
    Paliperidone (Standard)
    		Antagonist
    Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.
    Paliperidone (Standard)
  • HY-126057A
    (S)-Praziquantel
    		Control
    S)-Praziquantel is a inactive distomer of R-praziquantel.
    (S)-Praziquantel
  • HY-120939
    S14063
    		Antagonist
    S14063 is a potent 5-HT1A receptor antagonist. S14063 is devoid of β-adrenoceptor blocking properties.
    S14063
  • HY-70050
    Alosetron (Hydrochloride(1:X))
    		Antagonist
    Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.
    Alosetron (Hydrochloride(1:X))
  • HY-169786
    5-HT2A receptor agonist-5
    		Agonist
    5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A receptor agonist with a Ki value of 0.017 µM. 5-HT2A receptor agonist-5 shows antidepressant activity.
    5-HT2A receptor agonist-5
  • HY-105109B
    (S)-Cilansetron
    		Control
    (S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a 5-HT3 receptor antagonist that can be used in research related to irritable bowel syndrome.
    (S)-Cilansetron
  • HY-167668
    Tipindole
    		Antagonist
    Tipindole is a serotonin antagonist. Tipindole can be used in depression research.
    Tipindole
  • HY-15780S1
    Brexpiprazole-d8-1
    Brexpiprazole-d8-1 (OPC-34712-d8-1) is the deuterium labeled Brexpiprazole (HY-15780). Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM).
    Brexpiprazole-d<sub>8</sub>-1
  • HY-B0071AS
    Granisetron-d6 Hydrochloride
    		Antagonist
    Granisetron-d6 (Hydrochloride) (BRL 43694A-d6) is deuterium labeled Granisetron (Hydrochloride). Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
    Granisetron-d<sub>6</sub> Hydrochloride
  • HY-156239
    Dopamine D3 receptor ligand-5
    		Ligand
    Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with Ki values of 2.85 nM and 0.14 nM for D2R and D3R, respectively.
    Dopamine D3 receptor ligand-5
  • HY-14262R
    Vilazodone (Standard)
    		Agonist
    Vilazodone (Standard) is the analytical standard of Vilazodone. This product is intended for research and analytical applications. Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders.
    Vilazodone (Standard)
  • HY-90003AR
    Tianeptine (sodium salt) (Standard)
    		Agonist
    Tianeptine (sodium salt) (Standard) is the analytical standard of Tianeptine (sodium salt). This product is intended for research and analytical applications. Tianeptine sodium salt is a selective facilitator of 5-HT uptake. Tianeptine sodium salt has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine sodium salt has antidepressant, anxiolytic, analgesic and neuroprotective activities.
    Tianeptine (sodium salt) (Standard)
  • HY-159689
    Cloroperone
    		Inhibitor
    Cloroperone is a 5-HT2 receptor inhibitor with a Ki value of 4.5 nM. Cloroperone can be used in research on psychiatric disorders.
    Cloroperone
  • HY-121653B
    Flesinoxan hydrochloride
    		Agonist
    Flesinoxan hydrochloride is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan hydrochloride also has effective anxiolytic/antidepressant effects.
    Flesinoxan hydrochloride
  • HY-101377A
    R(+)-8-OH-DPAT hydrobromide
    		Agonist
    R(+)-8-OH-DPAT ((R)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is a potent 5-HT1A agonist. R(+)-8-OH-DPAT potentiates SUL (HY-B1059)-induced dopamine (DA) release in the medial prefrontal cortex (mPFC).
    R(+)-8-OH-DPAT hydrobromide
  • HY-W1023070
    4-fluoro MBZP
    4-fluoro MBZP is a new psychoactive substance that belongs to the phenylpiperazine class of compounds and can be used to study the 5-HT2 receptors in the central nervous system.
    4-fluoro MBZP
  • HY-103143
    SDZ 205-557 hydrochloride
    		Antagonist
    SDZ 205-557 hydrochloride is a selective 5-HT4 receptors antagonist. SDZ 205-557 hydrochloride can be used for neurological research.
    SDZ 205-557 hydrochloride
  • HY-B1473S1
    Serotonin-13C2,15N hydrochloride
    Serotonin-13C2,15N hydrochloride is the 13C- and 15N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
    Serotonin-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity